1998).Īpoptosis is a cell death process that removes toxic and/or useless cells during mammalian development.
Therefore, the cleavage of CAD inhibitor molecule DFF/ICAD, which cause Dnase activation and DNA degradation, is the hallmark of apoptotic cell death (Wylile et al. Upon cleavage of DFF/ICAD, a caspase activated deoxyribonuclease (CAD) is released and activated and eventually causes the degradation of DNA in the nuclei (Enari et al. Mouse homologue of human DFF was identified as a Dnase inhibitor designated ICAD (Enari et al. A human DNA fragmentation factor (DFF) was identified recently which was cleaved by caspase-3 during apoptosis (Liu et al. These death signals finally cause the degradation of chromosomal DNA by activated Dnase. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. Please refer to the Certificate of Analysis for the lot-specific concentration.Īpoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Polyclonal antibody raised against a peptide corresponding to amino acids 2-21 of mouse ICAD (Enari et al. Optimal working dilutions must be determined by end user. Mouse lung tissue lysate can be used as a positive control and a 45 kDa band should be detected.
2-21 of mouse ICAD) is an antibody against ICAD/DFF for use in WB. Liquid in PBS containing 0.02% sodium azide.Īnti-ICAD/DFF Antibody, N-terminus (a.a. Inhibitor of Caspase Activated DeoxyribonucleaseĪffinity purified immunoglobulin.100% Performance Guaranteed Key Specifications Table Species ReactivityĪnti-ICAD/DFF Antibody, NT (a.a.
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